Within the last decade, aesthe­tic medicine, expanding its scope, has increasingly availed itself of techni­ques and methods in connection with regene­rative medi­cine. They both focus on rese­arching more natural biologi­cal so­lutions and methods, sharing also the main goal of accelerating repair mecha­nisms, stimulating the ability to rege­nerate tissue within the cells themselves. Through useful cell lines (stem cells, mononuclear cells, PRP, Con­centrated Growth Factors et al.) or formulas which manage to stimulate the neo-formation of endogenous tissue, the sha­red objective is to effectively cure the tissue where traditio­nal therapies do not succeed. In this direction, substantial help has come from the deve­lopment of technologies which are at the base of the various energy-based devices (EBD) and which utilize energy sour­ces like light, heat, microwaves or focused electromagnetic fields (Laser, Pulsed Light, Ul­trasound, Radiofrequency). It is then not wrong to speak about Regenerative Aesthetic Medicine, which offers a range of highly-tolerable methodolo­gies and with downtime and risk of complication reduced to a minimum. This is what is happening with exosomes, which have become the most coveted molecules of the moment. We know that the­se microscopic vesicles, with a diameter between 30 and 150 nm, are released by al­most all the cells in our body and cover a fundamentally important role as they are na­tural messengers, able to tran­sport proteins, lipids and RNA between the cells. This makes them protagonists in intercell biological communication as well as in tissue regeneration processes. To make them even more powerful, researchers have adopted two avenues: Enriching them with other active ingredients to make them available in sterile vials, or coupling them with EBD treatments in order to merge both benefits, thereby expediting recovery time.

Indeed, exosomes possess great soothing properties, contribute to reducing re­covery time in the mana­gement of post-treatment inflammatory effects, but also amplify the effects of the so-called regenerative medicine.

“Exolight” cow-milk exoso­mes, developed by DEKA, facilitate communication between cells, regulate proliferation, differentia­tion and inflammatory re­sponse, also thanks to their formula enriched with vitamins, bleaching agents, and whi­ch stimulate collagen syn­thesis, regeneration and tissue repair, and modula­te immune response, redu­cing inflammation and faci­litating a pro-regenerative environment.

By means of fractional laser emissions, both ablative (CO2, Q-Switched Nd:YAG or Er:YAG) and non-ablative like RedTou­ch PRO 675nm wavelength or microablative like “CoolPeel” procedure, we create micro thermal columns, in other words micro channels, whi­ch make the skin temporarily more permeable, thereby fa­cilitating penetration by acti­ve molecules to the deepest layers of the epidermis. As a result the laser collagen pro­duction regenerating and sti­mulating properties combine with the exosomes, and poten­tial side effects are reduced.

The study of standardized protocols and synergistic the­rapies between laser techno­logies and exosome action will shortly become the gold standard of reference in the most advanced aesthetic me­dicine practices, and that will turn into a solid benefit both for patients, who will see more results more rapidly, and the professionals who will propo­se them.